anti- Ubiquilin 1 antibodyСпецификация| Clonality | polyclonal | | Host | Rabbit | | Specificity | Human, Rat | | Tested Application | ELISA, IHC, WB, IF | | Delivery Time | 2 to 4 working days | | Isotype | IgG | | Form | liquid | | Purification | Immunogen affinity purified | | Purity | ≥95% as determined by SDS-PAGE | | Uniprot ID | Q9UMX0 | | Calculated MW | 89 kDa | | Ссылка на страницу на сайте производителя | ссылка | | Инструкция | PDF | | Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) | | Background | UBQLN1, also known as DSK2 or Ubiquilin 1, is an ubiquitin-like proteinis contains a?N-terminal?ubiquitin-like?domain?and a C-terminal ubiquitin-associated domain.?They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation.Ubiquilin has also been shown to modulate accumulation of presenilin proteins, and is found in lesions associated with?Alzheimer's?and?Parkinson's?disease. Two transcript variants encoding different isoforms have been found for this gene. Higher levels of ubiquilin-1 in the brain decreased malformation of the APP molecule which plays a key role in triggering Alzheimers disease.Conversely, lower levels of ubiquilin-1 in the brain were associated with increased malformation of APP?(PMID: 21852239). This antibody detects 70kD band of UBQLN1. | | Immunogen | ubiquilin 1 | | Synonyms | DA41, DSK2, FLJ90054, hPLIC 1, PLIC 1, PLIC1, ubiquilin 1, UBQLN1, XDRP1 | | Recommended dilution | WB: 1:200-1:1000; IF: 1:10-1:100; IHC: 1:20-1:200 | Immunohistochemistry of paraffin-embedded human pancreas slide using FNab09196(UBQLN1 Antibody) at dilution of 1:50
 | rat brain tissue were subjected to SDS PAGE followed by western blot with FNab09196(Ubiquilin 1 Antibody) at dilution of 1:300
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Информация для заказа| Область использования: | Производство: | Fine Biotech | | Метод: | Антитела | | Объем: | 100µg | | Кат. номер: | FNab09196 | | Цена (с НДС 20%): | по запросу | В корзину  | Наименование: anti- Ubiquilin 1 antibody.
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