| Clonality | polyclonal |
| Host | Rabbit |
| Specificity | Human |
| Tested Application | ELISA, WB, IHC |
| Delivery Time | 2 to 4 working days |
| Isotype | IgG |
| Form | liquid |
| Purification | Immunogen affinity purified |
| Purity | ≥95% as determined by SDS-PAGE |
| Uniprot ID | Q9H171 |
| Gene ID | |
| Calculated MW | 49 kDa, Observed 66 kDa |
| Ссылка на страницу на сайте производителя | ссылка |
| Инструкция | PDF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| Background | Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor(IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3(By similarity). |
| Immunogen | Z-DNA binding protein 1 |
| Synonyms | ZBP1, C20orf183, DLM1, Z DNA binding protein 1, DLM 1 |
| Recommended dilution | WB: 1:500-1:5000; IHC: 1:20-1:200 |
Immunohistochemistry of paraffin-embedded human liver cancer using FNab09586(ZBP1 antibody) at dilution of 1:50
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Jurkat cells were subjected to SDS PAGE followed by western blot with FNab09586(ZBP1 antibody) at dilution of 1:400
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