| Clonality | polyclonal |
| Host | Rabbit |
| Specificity | Human |
| Tested Application | ELISA, IHC, WB |
| Delivery Time | 2 to 4 working days |
| Isotype | IgG |
| Form | liquid |
| Purification | Immunogen affinity purified |
| Purity | ≥95% as determined by SDS-PAGE |
| Uniprot ID | P09914 |
| Gene ID | |
| Calculated MW | 55 kDa |
| Ссылка на страницу на сайте производителя | ссылка |
| Инструкция | PDF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| Background | Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group(PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation(cap snatching mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses. |
| Immunogen | interferon-induced protein with tetratricopeptide repeats 1 |
| Synonyms | G10P1, IFI56, IFNAI1, ISG56 |
Immunohistochemistry of paraffin-embedded human breast cancer slide using FNab04135(IFIT1 Antibody) at dilution of 1:50
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U-937 cells were subjected to SDS PAGE followed by western blot with FNab04135(IFIT1 Antibody) at dilution of 1:600
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