anti- IFITM3 antibodyСпецификация| Clonality | monoclonal | | Host | Mouse | | Specificity | Human | | Tested Application | ELISA, WB, IF, IHC, FC | | Delivery Time | 2 to 4 working days | | Clone ID | 5H4 | | Isotype | IgG1 | | Form | liquid | | Purification | Protein A+G purification | | Purity | ≥95% as determined by SDS-PAGE | | Uniprot ID | Q01628 | | Gene ID | | | Calculated MW | 14 kDa | | Ссылка на страницу на сайте производителя | ссылка | | Инструкция | PDF | | Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) | | Background | IFN-induced antiviral protein which disrupts intracellular cholesterol homeostasis. Inhibits the entry of viruses to the host cell cytoplasm by preventing viral fusion with cholesterol depleted endosomes. May inactivate new enveloped viruses which buds out of the infected cell, by letting them go out with a cholesterol depleted membrane. Active against multiple viruses, including influenza A virus, SARS coronavirus(SARS-CoV), Marburg virus(MARV) and Ebola virus(EBOV), Dengue virus(DNV), West Nile virus(WNV), human immunodeficiency virus type 1(HIV-1) and vesicular stomatitis virus(VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral entry. Plays a critical role in the structural stability and function of vacuolar ATPase(v-ATPase). Establishes physical contact with the v-ATPase of endosomes which is critical for proper clathrin localization and is also required for the function of the v-ATPase to lower the pH in phagocytic endosomes thus establishing an antiviral state.This antibody recognizes both IFITM2 and IFITM3. | | Immunogen | IFITM2/3 fusion protein | | Synonyms | 1 8U, IFITM3, IP15 | | Recommended dilution | WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:10-1:100 | Immunohistochemistry of paraffin-embedded human lung cancer using FNab04145(IFITM3 antibody) at dilution of 1:50
 | HeLa cells were subjected to SDS PAGE followed by western blot with FNab04145(IFITM3 antibody) at dilution of 1:1000
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Информация для заказа| Область использования: | Производство: | Fine Biotech | | Метод: | Антитела | | Объем: | 100µg | | Кат. номер: | FNab04145 | | Цена (с НДС 20%): | по запросу | В корзину  | Наименование: anti- IFITM3 antibody.
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