anti- ZCCHC11 antibodyСпецификация| Clonality | polyclonal | | Host | Rabbit | | Specificity | Human | | Tested Application | ELISA, WB, IHC, IF | | Delivery Time | 2 to 4 working days | | Isotype | IgG | | Form | liquid | | Purification | Immunogen affinity purified | | Purity | ≥95% as determined by SDS-PAGE | | Uniprot ID | Q5TAX3 | | Gene ID | | | Calculated MW | 185 kDa | | Ссылка на страницу на сайте производителя | ссылка | | Инструкция | PDF | | Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) | | Background | Uridylyltransferase that mediates the terminal uridylation of mRNAs with short(less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay(PubMed:25480299). Involved in microRNA(miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets. Also acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7(pre-let-7), miR107, miR-143 and miR-200c. Uridylated miRNAs are not processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem(ES) cell pluripotency(By similarity). Does not bind RNA directly, but recruited to RNA targets by RNA-binding protein LIN28A. Also catalyzes the 3' uridylation of miR-26A, a miRNA that targets IL6 transcript. This abrogates the silencing of IL6 transcript, hence promoting cytokine expression(By similarity). May also suppress Toll-like receptor-induced NF-kappa-B activation via binding to T2BP. Does not play a role in replication-dependent histone mRNA degradation. Due to functional redundancy between ZCCHC6 and ZCCHC11, the identification of the specific role of each of these proteins is difficult. | | Immunogen | zinc finger, CCHC domain containing 11 | | Synonyms | KIAA0191, PAPD3, Terminal uridylyltransferase 4, TUT4, TUTase 4, ZCCHC11 | | Recommended dilution | WB: 1:200-1:2000; IHC: 1:20-1:200; IF: 1:10-1:100 | Immunohistochemistry of paraffin-embedded human brain using FNab09610(ZCCHC11 antibody) at dilution of 1:50
 | HeLa cells were subjected to SDS PAGE followed by western blot with FNab09610(ZCCHC11 antibody) at dilution of 1:300
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Информация для заказа| Область использования: | Производство: | Fine Biotech | | Метод: | Антитела | | Объем: | 100µg | | Кат. номер: | FNab09610 | | Цена (с НДС 20%): | по запросу | В корзину  | Наименование: anti- ZCCHC11 antibody.
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