Кроличьи поликлональные антитела к CD59 (H-85)CD59 (H-85)
- CD59 Antibody (H-85) is a rabbit polyclonal IgG provided at 200 µg/ml
- epitope corresponding to amino acids 26-110 mapping within an internal region of CD59 of human origin
- recommended for detection of CD59 of human origin by WB, IP, IF, IHC(P) and ELISA
CD59 is a GPI-anchored glycoprotein that is expressed on leukocytes, vascular endothelial cells, various epithelial cells and placenta. CD59 acts together with CD58 in mediating T cell adhesion and activation, and it may be a second ligand of CD2. CD59 functions as a regulator of the terminal pathway of complement by binding to the C8/C9 components of the assembling membrane attack complex (MAC) on host cell membranes, to stop the formation of the lytic pore. CD59 also drives both calcium release and activation of lipid-raft associated signalling molecules such as tyrosine kinases. CD59 gene has two p53-responsive domains that may be implicated in the defense of host cells from damage by the complement system in inflammation, suggesting that p53 could be used to mediate susceptibility of tumor cells to the complement lysis during chemotherapy. Информация для заказа| Область использования: | Производство: | Santa Cruz | | Метод: | | | Объем: | 200 мкг/мл | | Кат. номер: | sc-28805 | | Цена (с НДС 20%): | по запросу | В корзину  |  Наименование: Кроличьи поликлональные антитела к CD59 (H-85) / CD59 (H-85).
Примечание: Видоспецифичность: человек.
Описание: кроличий поликлональный IgG.
Приложение: вестерн блоттинг, иммунопреципитация, иммунофлуоресценция.
Доставка на голубом льду, хранение при 4°C.
Подробное описание (на английском языке). |
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