Антитела поликлональные кроличьи IgG к Bcl-2 (N-19)

Bcl-2 Antibody (N-19) is a rabbit polyclonal IgG

• Bcl-2 Antibody (N-19) is a rabbit polyclonal IgG provided at 200 µg/ml; also available as goat IgG provided at 200 µg/ml, sc-492-G
• epitope mapping at the N-terminus of Bcl-2 of human origin
• recommended for detection of Bcl-2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
• blocking peptide, sc-492 P
• agarose conjugate for IP studies, sc-492 AC, 500 µg/0.25 ml agarose
• HRP conjugate, sc-492 HRP, 200 µg/ml
• See 363 citations for Bcl-2 Antibody (N-19)

Apoptosis is defined as a set of cascades which, when initiated, programs the cell to undergo lethal changes such as membrane blebbing, mitochondrial break down and DNA fragmentation. Bcl-2 is one among many key regulators of apoptosis, which are essential for proper development, tissue homeostasis, and protection against foreign pathogens. Human Bcl-2 is an anti-apoptotic, membrane-associated oncoprotein that can promote cell survival through protein-protein interactions with other Bcl-2 related family members, such as the death suppressors Bcl-xl, Mcl-1, Bcl-w, and A1 or the death agonists Bax, Bak, Bik, Bad, and Bid. The anti-apoptotic function of Bcl-2 can also be regulated through proteolytic processing and phospho-rylation. Bcl-2 may promote cell survival by interfering with the activation of the cytochrome c/Apaf-1 pathway through stabilization of the mitochondrial membrane. Mutations in the Bcl-2 gene can contribute to cancers where normal physiological cell death mechanisms are compromised by deregulation of the anti-apoptotic influence of Bcl-2.

Информация для заказа

Область использования: Антитела к суппрессорам опухолей/ апоптическим белкам для вестерн-блоттинга Антитела к суппрессорам опухолей/ апоптическим белкам для иммунопреципитации Антитела к суппрессорам опухолей/ апоптическим белкам для иммунофлуоресценции Антитела к супрессорам опухолей/ апоптоз Первичные антитела и конъюгаты	Производство:	Santa Cruz
	Метод:
	Объем:	200 мкг/мл
	Кат. номер:	sc-492
Цена (с НДС 20%):	по запросу	В корзину
Наименование: Антитела поликлональные кроличьи IgG к Bcl-2 (N-19) / Bcl-2 Antibody (N-19) is a rabbit polyclonal IgG. Примечание: SQ Category: Primary Antibodies, Species: m, r, h, Host Origin: human, Applications: WB, IP, IF, IHC(P), ELISA, UNSPSC: 12352203, datasheet