Набор Relative Rat Telomerase Length Quantification qPCR Assay Kit

Relative Rat Telomere Length Quantification qPCR Assay Kit

ScienCell's Relative Rat Telomere Length Quantification qPCR Assay Kit (RRTLQ) is designed to directly compare the average telomere length of the samples.

 

Telomeres are repetitive nucleotide elements at the ends of chromosomes that protect chromosomes from degradation and genetic information loss. Normal diploid cells lose telomeres with each cell cycle. Telomere length, therefore, decreases over time and may predict lifespan. Telomere shortening has negative effects on health conditions and has been linked to many health issues including aging and cancer. Accurate and consistent quantification of telomere length is important in many aspects of cell biology such as chromosomal instability, DNA repair, senescence, apoptosis, cell dysfunctions, and oncogenesis.

ScienCell's Relative Rat Telomere Length Quantification qPCR Assay Kit (RRTLQ) is designed to directly compare the average telomere length of the samples. The telomere primer set recognizes and amplifies telomere sequences. The single copy reference (SCR) primer set recognizes and amplifies a 100 bp-long region on rat chromosome 17, and serves as reference for data normalization. The carefully designed primers ensure: (i) high efficiency for trustworthy quantification; and (ii) no non-specific amplification. Each primer set has been validated by qPCR with melt curve analysis and gel electrophoresis for amplification specificity and by template serial dilution for amplification efficiency.

Product Sheets

R8908

Catalog No.	R8908
Country of Manufacture	United States
Product Code	RRTLQ
Size/Quantity	100 reactions
Product Use	This product is for research use only. It is not approved for use in humans, animals, or in vitro diagnostic procedures.
Storage	Upon receipt, store the primers at -20°C in a manual defrost freezer, and nuclease-free H2O at 4°C.
Shipping Info	Ambient temperature.

 

1.) Martin LF, Richardson LS, da Silva MG, Sheller- Miller S, Menon R. (2019) Dexamethasone Induces Primary Amnion Epithelial Cell Senescence through Telomere-P21 Associated Pathway. Biology of Reproduction.

2.) Bruno S, Sanchez MBH, Pasquino C, Tapparo M, Cedrino M, Tetta C, Camussi G. (2019) "Human Liver-Derived Stem Cells Improve Fibrosis and Inflammation Associated with Nonalcoholic Steatohepatitis." Stem Cells International. 2019

3.) Wysoczanska B, Dratwa M, Gebura K, Mizgala J, Mazur G, Wrobel T, Bogunia-Kubik K. (2019) "Variability Within the Human TERT Gene, Telomere Length and Predisposition to Chronic Lymphocytic Leukemia." OncoTargets and Therapy. 12:4309-4320

4.) Chung SS, Dutta P, Chard N, Wu Y, Chen QH, Chen G, Vadgama J. (2019) "A novel curcumin analog inhibits canonical and non-canonical functions of telomerase through STAT3 and NF-kB inactivation in colorectal cancer cells." Oncotarget. 10(44):4516-4531

5.) Babu H, Ambikan AT, Gabriel EE, Akusjarvi SS, Mupanni NR, Sperk M, Cheedarla N, Palaniapan AN, Sridhar R, Sundaraj V, Tripathy SP, Nowak P, Hanna LE, Neogi U. (2018) Systemic inflammation following long-term successful antiretroviral therapy in people living with HIV (PLHIV). bioRxiv preprint.

6.) Iezzi I, Cerqueni G, Licini c, Lucarini G, Belmonte M. (2018) Dental pulp stem cells senescence and regenerative potential relationship. Journal of Cellular Physiology. 234(5):7186-7197

7.) Lazzarini R, Nicolai M, Pirani V, Mariorri C, DiPrimio R. (2018) Effects of senescent secretory phenotype acquisition on human retinal pigment epithelial stem cells. Aging. 10(11):3173-3184

8.) Shirato K, Takanari J, Koda T, Sakurai T, Ogasawara J, Ohno H, Kizaki T. (2018) A standardized extract of Asparagus officinalis stem prevents reduction in heat shock protein 70 expression in ultraviolet-B-irradiated normal human dermal fibroblasts: an in vitro study. Environmental Health and Preventative Medicine. 23:40

ScienCell Research Laboratories (SRL) takes pride in being a resource for researchers all over the world. The publications listed here are not meant as an endorsement or confirmation of the reliability of the research methods. Our sole intention of sharing the research publications listed here is to provide research related insights and innovations of our products with other researchers.

Информация для заказа

Область использования: Реагенты для исследования стволовых клеток ScienCell Research Laboratories, Inc. Реагенты и тест-системы для ПЦР ScienCell Research Laboratories, Inc.	Производство:	ScienCell Research Laboratories, Inc.
	Метод:	ПЦР
	Объем:	100 reactions
	Кат. номер:	R8908
Цена (с НДС 20%):	по запросу	В корзину
Наименование: Набор Relative Rat Telomerase Length Quantification qPCR Assay Kit / Relative Rat Telomere Length Quantification qPCR Assay Kit. Примечание: Набор для количественного определения относительной длины теломер крысы