Anti-Human CD196/CCR6 Monoclonal Antibody(APC Conjugated)Спецификация| Описание | CCR6, also known as CD196/CCR6, is a chemokine receptor that is expressed on immature dendritic cells, B lymphocytes, and memory T cells. CCR6 binds CCL20, although members of the β defensin family also bind CCR6 with a lower affinity. CCR6 positive cells, and its ligand CCL20, have been detected in numerous organs, especially the secondary lymphoid organ. CCL20 is selectively made by the follicle-associated epithelium (FAE) overlying Peyers Patches (PPs) and isolated lymphoid follicles (ILFs). CCL20 contributes to the recruitment of CCR6-expressing B cells to these structures. In humans, CCR6 can function to mediate arrest of T cells on dermal endothelial cells and is highly expressed on T cells resident in both normal and psoriatic skin. CCR6 and/or CCL20 have been implicated in the pathogenesis of rheumatoid arthritis and inflammatory bowel disease. Human T cells that are able to produce IL-17 express CCR6. It suggests that CCL20 and CCR6 have a role in inflammatory diseases by recruiting Th17 cells to target tissues. | | Метод | FCM | | Хозяин | Mouse | | Специфичность | Human | | Коньюгат | APC | | Буфер | PBS with 0.05% Proclin300, 1% BSA | | Клон |
G034E3 | | Gene_ID | 1235 | | Swissprot | P51684 | | Isotype | Mouse IgG2b, κ | | Хранение | Store at 2~8℃ and protected from prolonged exposure to light. Do not freeze. | | Описание на сайте производителя | ссылка | | | |
Информация для заказа| Область использования: | Производство: | DLDEVELOP | | Метод: | Антитела | | Объем: | 50 tests | | Кат. номер: | DL21846F-50 | | Цена (с НДС 20%): | по запросу | В корзину  |  Наименование: Anti-Human CD196/CCR6 Monoclonal Antibody(APC Conjugated).
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