Anti-Human/Mouse/Rat Foxp3 Monoclonal Antibody(AF647 Conjugated)Спецификация| Описание | FOXP3 is a 50-55 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of FOXP3 in CD4+/CD25- cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in "scurfy" mice. Overexpression of FOXP3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity. In human, unlike in mouse, two isoforms of FOXP3 have been reported: one (FOXP3) corresponding to the canonical full-length sequence; the other (FOXP3 δ2) lacking exon 2. The 150D monoclonal antibody reacts with human, mouse and rat FOXP3. The 150D antibody recognizes FOXP3 epitope encoded by exon 2. | | Метод | ICFCM | | Хозяин | Mouse | | Специфичность | Human, Mouse, Rat | | Коньюгат | AF647 | | Буфер | PBS with 0.05% Proclin300, 1% BSA | | Клон | 150D | | Gene_ID | 50943,20371,317382 | | Swissprot | Q9BZS1,Q99JB6 | | Isotype | Mouse IgG1, κ | | Хранение | Store at 2~8℃. Do not freeze. | | Описание на сайте производителя | ссылка | | | |
Информация для заказа| Область использования: | Производство: | DLDEVELOP | | Метод: | Антитела | | Объем: | 200 tests | | Кат. номер: | DL22212F-200 | | Цена (с НДС 20%): | по запросу | В корзину  |  Наименование: Anti-Human/Mouse/Rat Foxp3 Monoclonal Antibody(AF647 Conjugated).
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