p53 Antibody (FL-393) is a rabbit polyclonal IgG

• p53 Antibody (FL-393) is a rabbit polyclonal IgG provided at 200 µg/ml; also available as goat IgG provided at 200 µg/ml, sc-6243-G
• epitope mapping within amino acids 1-393 representing full length p53 of human origin
• recommended for detection of p53 of mouse, rat and human origin by WB, IP, IF, IHC(P), FCM and ELISA
• agarose conjugate for IP studies, sc-6243 AC, 500 µg/0.25 ml agarose
• Alexa Fluor^® 405 (sc-6243 AF405), Alexa Fluor^® 488 (sc-6243 AF488) and Alexa Fluor^® 647 (sc-6243 AF647) conjugates for FCM or immunofluorescence; 100 µg/2 ml
• HRP conjugate, sc-6243 HRP, 200 µg/ml
• TransCruz reagent for Gel Supershift and ChIP applications, sc-6243 X, 200 µg/0.1 ml
• fluorescein (sc-6243 FITC) and phycoerythrin (sc-6243 PE) conjugates for FCM, 100 tests
• See 563 citations for p53 Antibody (FL-393)

p53, a DNA-binding, oligomerization domain- and transcription activation domain-containing tumor suppressor, upregulates growth arrest and apoptosis-related genes in response to stress signals, thereby influencing programmed cell death, cell differentiation, and cell cycle control mechanisms. p53 localizes to the nucleus, yet can be chaperoned to the cytoplasm by the negative regulator, MDM2. MDM2 is an E3 ubiquitin ligase that is upregulated in the presence of active p53, where it poly-ubiquitinates p53 for proteasome targeting. p53 fluctuates between latent and active DNA-binding conformations and is differentially activated through posttranslational modifications, including phosphorylation and acetylation. Mutations in the DNA-binding domain (DBD) of p53, amino acids 110-286, can compromise energetically-favorable association with cis elements and are implicated in several human cancers.

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Область использования: Антитела к суппрессорам опухолей / апоптическим белкам для проточной цитометрии Антитела к суппрессорам опухолей/ апоптическим белкам для вестерн-блоттинга Антитела к суппрессорам опухолей/ апоптическим белкам для иммунопреципитации Антитела к суппрессорам опухолей/ апоптическим белкам для иммунофлуоресценции Антитела к супрессорам опухолей/ апоптоз Первичные антитела и конъюгаты	Производство:	Santa Cruz
	Метод:
	Объем:	200 мкг/мл
	Кат. номер:	sc-6243
Цена (с НДС 20%):	по запросу	В корзину
Наименование: p53 Antibody (FL-393) is a rabbit polyclonal IgG. Примечание: SQ Category: Primary Antibodies, Species: m, r, h, Host Origin: human, Applications: WB, IP, IF, IHC(P), FCM, ELISA, UNSPSC: 12352203, datasheet