Антитела мышиные моноклональные IgG2a к Toll-подобный рецептор TLR4 (HTA125)

TLR4 Antibody (HTA125) is a mouse monoclonal IgG2a

• TLR4 Antibody (HTA125) is a mouse monoclonal IgG_2a provided at 200 µg/ml
• raised against Toll-like receptor 4 (TLR4)
• recommended for detection of TLR4/MD-2 complex of human origin by IP, IF, IHC(P) and indirect FCM using Avidin-PE (sc-2876) or Avidin-FITC (sc-2865) conjugates
• also provided azide-free for inhibitory studies, sc-13593 L, 200 µg/0.1 ml
• fluorescein (sc-13593 FITC), phycoerythrin (sc-13593 PE), PerCP (sc-13593 PerCP) and PerCP-Cy5.5 (sc-13593 PCPC5) conjugates for FCM, 100 tests
• Alexa Fluor^® 405 (sc-13593 AF405), Alexa Fluor^® 488 (sc-13593 AF488) and Alexa Fluor^® 647 (sc-13593 AF647) conjugates for FCM or immunofluorescence; 100 µg/2 ml

Six human homologs of the Drosophila Toll receptor were initially identified based on their sequence similarities and designated toll-like receptors (TLR). Toll receptors are involved in mediating dorsoventral polarization in the developing Drosophila embryo and also participate in the host immunity. The TLR family of proteins are characterized by a highly conserved Toll homology (TH) domain, which is essential for Toll-induced signal transduction. TLR1, as well as the other TLR family members, are type I transmembrane receptors that characteristically contain an extracellular domain consisting of several leucine-rich regions along with a single cytoplasmic Toll/IL-1R-like domain. TLR2 and TLR4 are activated in response to lipopolysacchride (LPS) stimulation, which results in the activation and translocation of NFkB and suggests that these receptors are involved in mediating inflammatory responses. Expression of TLR receptors is highest in peripheral blood leukocytes, macro-phages, and monocytes. TLR6 is highly homologous to TLR1, sharing greater than 65% sequence identity, and, like other members of TLR family, it induces NFkB signaling upon activation.

Информация для заказа

Область использования: Антитела к мембранным рецепторам Антитела к мембранным рецепторам для иммунопреципитации Антитела к мембранным рецепторам для иммунофлуоресценции Антитела к мембранным рецепторам для проточной цитометрии Первичные антитела и конъюгаты	Производство:	Santa Cruz
	Метод:
	Объем:	200 мкг/мл
	Кат. номер:	sc-13593
Цена (с НДС 20%):	по запросу	В корзину
Наименование: Антитела мышиные моноклональные IgG2a к Toll-подобный рецептор TLR4 (HTA125) / TLR4 Antibody (HTA125) is a mouse monoclonal IgG2a . Примечание: SQ Category: Primary Antibodies, Species: human, Host Origin: human, Applications: IP, IF, IHC(P), FCM, UNSPSC: 12352203, datasheet