p130 Antibody (C-20) is a rabbit polyclonal IgG
- p130 Antibody (C-20) is a rabbit polyclonal IgG provided at 200 µg/ml; also available as goat IgG provided at 200 µg/ml, sc-317-G
- epitope mapping at the C-terminus of p130 of human origin
- recommended for detection of p130 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
- agarose conjugate for IP studies, sc-317 AC, 500 µg/0.25 ml agarose
- blocking peptide, sc-317 P
- TransCruz reagent for Gel Supershift and ChIP applications, sc-317 X, 200 µg/0.1 ml
- See 266 citations for p130 Antibody (C-20)
The human retinoblastoma gene product Rb plays an important role in the negative regulation of cell proliferation. The Rb family includes p107 and p130, which form complexes with E2F proteins, and share a high degree of structural homology in the adenovirus E1A binding domain (i.e., “pocket region”), which plays a primary role in the function of these proteins. The Rb family members undergo cell cycle dependent phosphorylation during mid-G1 to S phase transition, which is dependent upon the activity of cyclin D/cdk4. In contrast to pRb and p107, p130 is also phosphorylated during G0 and the early G1 phase of the cell cycle. p130 is specifically phosphorylated on serine and threonine residues in cells arrested in G0 by serum deprivation or density arrest, and these residues are clustered within a short co-linear region unique to p130 defined as the Loop. Информация для заказа| Область использования: | Производство: | Santa Cruz | | Метод: | | | Объем: | 200 мкг/мл | | Кат. номер: | sc-317 | | Цена (с НДС 20%): | по запросу | В корзину  |  Наименование: p130 Antibody (C-20) is a rabbit polyclonal IgG.
Примечание: SQ Category: Primary Antibodies,
Species: m, r, h,
Host Origin: human,
Applications: WB, IP, IF, ELISA,
UNSPSC: 12352203,
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