Объем | 100 мкл |
Синонимы | ICE-like apoptotic protease 6 |
Клональность | Polyclonal Antibody |
Организм | Human |
uniprot | P55211 |
Иммуноген | Peptide sequence around aa.301~305 (T-S-P-E-D) derived from Caspase 9 |
Источник | Rabbit |
Видовая специфичность | Human |
Применение | ELISA, WB,WB:1:500-1:1000 |
Примечание | Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.<br/><br/>Zou, H. et al. (1999) J. Biol. Chem. 274, 11549-11556.<br/>Deveraux, Q. L. et al. (1998) EMBO J. 17, 2215-2223.<br/>Li, P. et al. (1997) Cell 91, 479-489.<br/> |
Клональность1 | Polyclonal |
Изотип | IgG |
Коньюгат | Non-conjugated |
Буффер | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Форма | liquid |
Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
Метод очистки | Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. |
Области исследований | Cancer,Cell biology,Metabolism |
Ссылка на страницу на сайте производителя | ссылка |
Western blot analysis of extracts from 293 and Hela cells using Caspase 9 Antibody.
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