FOXO1 (Ab-256) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | FOXO1 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q12778 | | Иммуноген | Peptide sequence around aa.254~258 (A-A-S-M-D) derived from Human FKHR/FOXO1A. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB, IHC, IF,WB:1:500-1:1000, IHC:1:50-1:200, IF:1:100-1:200 | | Примечание | <p>FKHR belongs to the forkhead family of transcription factors, which are characterized by a distinct forkhead domain. It may play a role in myogenic growth and differentiation. The mammalian DAF-16-like transcription factors, FKHR, FKHRL1, and AFX, function as key regulators of insulin signaling, cell cycle progression, and apoptosis downstream of phosphoinositide 3-kinase. Gene activation through binding to insulin response sequences has been essential for mediating these functions. D-type Cyclins (in Class III) is required for FKHR mediated inhibition of cell cycle progression and transformation. FKHR gene is mapped to chromosome 13q14 <br /><br />Gan L, et al. (2005) J Neurochem, 93(5): 1209-19. <br />Smith WW, et al. (2005) J Cell Biol, 169(2): 331-9. <br />Di Maira G, et al. (2005) Cell Death Differ, 12(6): 668-77. <br />Horn S, et al. (2004) Leukemia, 18(11): 1839-49. <br />Zhao X, et al. (2004) Biochem J 4, 378(Pt 3): 839-49.</p> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. | | Области исследований | Epigenetics and Nuclear Signaling,Neuroscience,Cancer,Metabolism,Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from Hela cells using FKHR(Ab-256) Antibody.
 | Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using FKHR(Ab-256) Antibody(left) or the same antibody preincubated with blocking peptide(right).
 | Immunofluorescence staining of methanol-fixed Hela cells using FKHR(Ab-256) Antibody.
 | | | |
Информация для заказа |
Наименование: FOXO1 (Ab-256) Antibody.