| Объем | 50 мкг |
| Синонимы | Mitofusin-2 (EC 3.6.5.-) (Transmembrane GTPase MFN2), MFN2, CPRP1 KIAA0214 |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | O95140 |
| Иммуноген | Recombinant Human Mitofusin-2 protein (61-158AA) |
| Источник | Rabbit |
| Видовая специфичность | Human, Rat |
| Применение | ELISA, WB, IHC, Recommended dilution: WB:1:200-1:3000, IHC:1:20-1:200 |
| Примечание | Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN2 acts independently of the cytoskeleton. It therefore plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Overexpression induces the formation of mitochondrial networks. Plays an important role in the regulation of vascular smooth muscle cell proliferation. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). Is required for PARK2 recruitment to dysfunctional mitochondria. Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress. Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions. |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Preservative: 0.03% Proclin 300<br />Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Форма | Liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | >95%, Protein G purified |
| Абревеатура | Mitofusin-2 |
| Области исследований | Neuroscience, Cancer, Cell biology, Tags & Cell Markers, Metabolism, Signal transduction |
| Ссылка на страницу на сайте производителя | ссылка |
Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA013756LA01HU at dilution of 1:100
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Western Blot
Positive WB detected in: Rat kidney tissue
All lanes: MFN2 antibody at 3µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 89, 51 kDa
Observed band size: 89 kDa
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Наименование: MFN2 Antibody.