CREB1 (Ab-129) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | CREB-1, CREB1, | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P16220 | | Иммуноген | Peptide sequence around aa.127~131 (I-L-S-R-R) derived from Human CREB. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB, IHC,WB:1:500-1:1000, IHC:1:50-1:200 | | Примечание | CREB1 is a transcription factor that is a member of the bZIP family of DNA binding proteins. It binds as a homodimer to the CRE (cAMP-Responsive Element), an octameric palindrome containing a conserved core sequence, 5-prime-TGACG-3-prime. It consists of two transcript variants encoding respective isoforms produced by alternate splicing. It is mapped to 2q32.3-q34 . It is phosphorylated by several protein kinases and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. CREB1 is crucial for the consolidation of long-term conditioned fear memories, but not for encoding, storage, or retrieval of these memories. It is required for the stability of reactivated or retrieved conditioned fear memories .<br/><br/>Chrystelle V. Garat, et al. (2006) Mol. Cell. Biol , 26: 4934 - 4948.<br/>Lilah Rothem,et al. (2004) Mol. Pharmacol , 66: 1536 - 1543.<br/>Darren R. Tyson, et,al. (2002) Endocrinology, 143: 674.<br/>Kyung-Woo Park, et al. (2003) Arterioscler. Thromb. Vasc. Biol , 23: 1364.<br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. | | Области исследований | Epigenetics and Nuclear Signaling,Immunology | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from Hela and HT29 cells using CREB(Ab-129) Antibody.
 | Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using CREB(Ab-129) Antibody(left) or the same antibody preincubated with blocking peptide(right).
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Наименование: CREB1 (Ab-129) Antibody.