Recombinant Grammostola Kappa-theraphotoxin-Gr1a protein

Relevance: Inhibits Kv2.1/KCNB1 and Kv4.2/KCND2 voltage-gated potassium channels. Acts as a gating modifier by shifting channel openings to more depolarized voltages and acts via the occupancy of multiple binding sites on the channel. The toxin binding sites are situated on the S3-S4 extracellular linker of the channel. At least two hanatoxin molecules can occupy the Kv2.1/KCNB1 channel, and maybe more (three or four). Can also inhibit calcium channels (Cav2.1/CACNA1A). Needs to partition into the membrane in order to bind to the channel.
Product Info: GST tagged
Source: E.coli derived
Purity: 90%
Image:
Tested applications: SDS-PAGE, ELISA
Storage Buffer: PBS buffer, 20mM GSH
Storage: Store at -20?, for extended storage, conserve at -20? or -80?.
Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
AA sequence: ECRYLFGGCKTTSDCCKHLGCKFRDKYCAWDFTFS
Referrences: [1] "An inhibitor of the Kv2.1 potassium channel isolated from the venom of a Chilean tarantula." Swartz K.J., MacKinnon R. Neuron 15:941-949(1995) [PubMed: 7576642] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Venom. [2] "Hanatoxin modifies the gating of a voltage-dependent K+ channel through multiple binding sites." Swartz K.J., MacKinnon R. Neuron 18:665-673(1997) [PubMed: 9136774] [Abstract] Cited for: FUNCTION. [3] "Mapping the receptor site for hanatoxin, a gating modifier of voltage-dependent K+ channels." Swartz K.J., MacKinnon R. Neuron 18:675-682(1997) [PubMed: 9136775] [Abstract] Cited for: FUNCTION.
Alias: Kappa-TRTX-Gr1a,Hanatoxin-1,HaTx1.

Информация для заказа

Область использования: Рекомбинантные белки Cusabio	Производство:	Cusabio
	Метод:
	Объем:	500 мкг
	Кат. номер:	CSB-RP076944Gr
Цена (с НДС 20%):	по запросу	В корзину
Наименование: Recombinant Grammostola Kappa-theraphotoxin-Gr1a protein. Примечание: дополнительная информация (на английском языке).