Recombinant human Angiopoietin-2 protein

Relevance: Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.
Product Info:
Source:
Purity: 90%
Image:
Tested applications: SDS-PAGE, ELISA
Storage Buffer: 6M guanidine hydrochloride, 20mM Tris
Storage: Store at -20?, for extended storage, conserve at -20? or -80?.
Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
AA sequence:
Referrences: [1] "Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis." Maisonpierre P.C., Suri C., Jones P.F., Bartunkova S., Wiegand S.J., Radziejewski C., Compton D.L., McClain J., Aldrich T.H., Papadopoulos N., Daly T.J., Davis S., Sato T.N., Yancopoulos G.D. Science 277:55-60(1997) [PubMed: 9204896] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH TEK/TIE2, FUNCTION. Tissue: Lung. [2] "Biologic significance of angiopoietin-2 expression in human hepatocellular carcinoma." Tanaka S., Mori M., Sakamoto Y., Makuuchi M., Sugimachi K., Wands J.R. J. Clin. Invest. 103:341-345(1999) [PubMed: 9927494] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3). [3] "Characterization and expression of a novel alternatively spliced human angiopoietin-2." Kim I., Kim J.-H., Ryu Y.S., Jung S.H., Nah J.J., Koh G.Y. J. Biol. Chem. 275:18550-18556(2000) [PubMed: 10766762] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Umbilical vein endothelial cell.
Alias: .

Информация для заказа

Область использования: Рекомбинантные белки Cusabio	Производство:	Cusabio
	Метод:
	Объем:	10 мкг
	Кат. номер:	CSB-RP057474h
Цена (с НДС 20%):	по запросу	В корзину
Наименование: Recombinant human Angiopoietin-2 protein. Примечание: дополнительная информация (на английском языке).