Recombinant human Cellular tumor antigen p53 protein

Relevance: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.
Product Info:
Source:
Purity: 90%
Image:
Tested applications: SDS-PAGE, ELISA
Storage Buffer: PBS buffer, 20mM GSH
Storage: Store at -20?, for extended storage, conserve at -20? or -80?.
Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
AA sequence:
Referrences: [1] "Human p53 cellular tumor antigen: cDNA sequence and expression in COS cells." Zakut-Houri R., Bienz-Tadmor B., Givol D., Oren M. EMBO J. 4:1251-1255(1985) [PubMed: 4006916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). [2] "Characterization of the human p53 gene." Lamb P., Crawford L. Mol. Cell. Biol. 6:1379-1385(1986) [PubMed: 2946935] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), VARIANT GLY-76. [3] "Molecular cloning and in vitro expression of a cDNA clone for human cellular tumor antigen p53." Harlow E., Williamson N.M., Ralston R., Helfman D.M., Adams T.E. Mol. Cell. Biol. 5:1601-1610(1985) [PubMed: 3894933] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Alias: Antigen NY-CO-13,Phosphoprotein p53,Tumor suppressor p53.

Информация для заказа

Область использования: Рекомбинантные белки Cusabio	Производство:	Cusabio
	Метод:
	Объем:	1 мг
	Кат. номер:	CSB-RP078844h
Цена (с НДС 20%):	по запросу	В корзину
Наименование: Recombinant human Cellular tumor antigen p53 protein. Примечание: дополнительная информация (на английском языке).