Recombinant human E3 ubiquitin-protein ligase MIB1 protein

Relevance: E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis
Product Info:
Source:
Purity: 90%
Image:
Tested applications: SDS-PAGE, ELISA
Storage Buffer: 6M guanidine hydrochloride, 20mM Tris
Storage: Store at -20?, for extended storage, conserve at -20? or -80?.
Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
AA sequence:
Referrences: [1] "Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta." Itoh M., Kim C.-H., Palardy G., Oda T., Jiang Y.-J., Maust D., Yeo S.-Y., Lorick K., Wright G.J., Ariza-McNaughton L., Weissman A.M., Lewis J., Chandrasekharappa S.C., Chitnis A.B. Dev. Cell 4:67-82(2003) [PubMed: 12530964] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. [2] Yoo K.-W., Chitnis A., Kim C.-H. Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. [3] NHLBI resequencing and genotyping service (RS&G) Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Alias: DAPK-interacting protein 1 Short name=DIP-1 Mind bomb homolog 1 Zinc finger ZZ type with ankyrin repeat domain protein 2.

Информация для заказа

Область использования: Рекомбинантные белки Cusabio	Производство:	Cusabio
	Метод:
	Объем:	500 мкг
	Кат. номер:	CSB-RP132874h
Цена (с НДС 20%):	по запросу	В корзину
Наименование: Recombinant human E3 ubiquitin-protein ligase MIB1 protein. Примечание: дополнительная информация (на английском языке).