Recombinant human Epidermal growth factor receptor protein

Relevance: Cell surface receptor for EGF, but also for other members of the EGF family, such as TGF-alpha, BTC/betacellulin, AREGAREGB/amphiregulin, HBEGF, GP30 and vaccinia virus growth factor. Ligand binding triggers a conformation change, leading to activation of the kinase and subsequent phosphorylation of down-stream protein kinases. Is involved in the control of cell growth, proliferation and differentiation. Phosphorylates MUC1 in breast cancer cells and increases the interaction of MUC1 with SRC and CTNNB1/beta-catenin. Ref.33 Ref.55 Ref.56 Ref.57 Ref.61 Ref.64 Ref.66 Isoform 2 may act as an antagonist of EGF action. Ref.33 Ref.55 Ref.56 Ref.57 Ref.61 Ref.64 Ref.66
Product Info:
Source:
Purity: 90%
Image:

 

Tested applications: SDS-PAGE, ELISA
Storage Buffer: 6M guanidine hydrochloride, 20mM Tris
Storage: Store at -20?, for extended storage, conserve at -20? or -80?.
Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
AA sequence:
Referrences: [1] "Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells." Ullrich A., Coussens L., Hayflick J.S., Dull T.J., Gray A., Tam A.W., Lee J., Yarden Y., Libermann T.A., Schlessinger J., Downward J., Mayes E.L.V., Whittle N., Waterfield M.D., Seeburg P.H. Nature 309:418-425(1984) [PubMed: 6328312] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). [2] "Possible role of variant RNA transcripts in the regulation of epidermal growth factor receptor expression in human placenta." Ilekis J.V., Stark B.C., Scoccia B. Mol. Reprod. Dev. 41:149-156(1995) [PubMed: 7654368] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Placenta. [3] "A 1.8 kb alternative transcript from the human epidermal growth factor receptor gene encodes a truncated form of the receptor." Reiter J.L., Maihle N.J. Nucleic Acids Res. 24:4050-4056(1996) [PubMed: 8918811] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 2). Tissue: Placenta. [4] "Expression of a truncated epidermal growth factor receptor-like protein (TEGFR) in ovarian cancer." Ilekis J.V., Gariti J., Niederberger C., Scoccia B. Gynecol. Oncol. 65:36-41(1997) [PubMed: 9103388] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Placenta. [5] "Comparative genomic sequence analysis and isolation of human and mouse alternative EGFR transcripts encoding truncated receptor isoforms." Reiter J.L., Threadgill D.W., Eley G.D., Strunk K.E., Danielsen A.J., Schehl Sinclair C., Pearsall R.S., Green P.J., Yee D., Lampland A.L., Balasubramaniam S., Crossley T.D., Magnuson T.R., James C.D., Maihle N.J. Genomics 71:1-20(2001) [PubMed: 11161793] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 3 AND 4). Tissue: Placenta.
Alias: Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1.

Информация для заказа

Область использования: Рекомбинантные белки Cusabio	Производство:	Cusabio
	Метод:
	Объем:	200 мкг
	Кат. номер:	CSB-RP102774h
Цена (с НДС 20%):	по запросу	В корзину
Наименование: Recombinant human Epidermal growth factor receptor protein. Примечание: дополнительная информация (на английском языке).