Recombinant human Glutamate carboxypeptidase 2 protein

Relevance: Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Isoform PSM-4 and isoform PSM-5 would appear to be physiologically irrelevant. Involved in prostate tumor progression. Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC.
Product Info:
Source:
Purity: 90%
Image:
Tested applications: SDS-PAGE, ELISA
Storage Buffer: 6M guanidine hydrochloride, 20mM Tris
Storage: Store at -20?, for extended storage, conserve at -20? or -80?.
Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
AA sequence:
Referrences: [1] "Molecular cloning of a complementary DNA encoding a prostate-specific membrane antigen." Israeli R.S., Powell C.T., Fair W.R., Heston W.D.W. Cancer Res. 53:227-230(1993) [PubMed: 8417812] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM PSMA-1), PARTIAL PROTEIN SEQUENCE. Tissue: Prostatic carcinoma. [2] "Alternatively spliced variants of prostate-specific membrane antigen RNA: ratio of expression as a potential measurement of progression." Su S.L., Huang I.-P., Fair W.R., Powell C.T., Heston W.D.W. Cancer Res. 55:1441-1443(1995) [PubMed: 7882349] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM PSMA'). Tissue: Prostate. [3] "Mapping, genomic organization and promoter analysis of the human prostate-specific membrane antigen gene." O'Keefe D.S., Su S.L., Bacich D.J., Horiguchi Y., Luo Y., Powell C.T., Zandvliet D., Russell P.J., Molloy P.L., Nowak N.J., Shows T.B., Mullins C., Vonder Haar R.A., Fair W.R., Heston W.D.W. Biochim. Biophys. Acta 1443:113-127(1998) [PubMed: 9838072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM PSMA-1), VARIANT HIS-75.
Alias: Cell growth-inhibiting gene 27 protein Folate hydrolase 1 Folylpoly-gamma-glutamate carboxypeptidase Short name=FGCP Glutamate carboxypeptidase II Short name=GCPII Membrane glutamate carboxypeptidase Short name=mGCP N-acetylated-alpha-linked acidic dipeptidase I Short name=NAALADase I Prostate-specific membrane antigen Short name=PSM Short name=PSMA Pteroylpoly-gamma-glutamate carboxypeptidase.

Информация для заказа

Область использования: Рекомбинантные белки Cusabio	Производство:	Cusabio
	Метод:
	Объем:	50 мкг
	Кат. номер:	CSB-RP117274h
Цена (с НДС 20%):	по запросу	В корзину
Наименование: Recombinant human Glutamate carboxypeptidase 2 protein. Примечание: дополнительная информация (на английском языке).