Recombinant human Heterogeneous nuclear ribonucleoprotein Q protein

Relevance: Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Isoform 1, isoform 2 and isoform 3 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins.
Product Info: GST-tagged
Source: E.coli derived
Purity: 95%
Image:
Tested applications: SDS-PAGE, ELISA, Western blot
Storage Buffer: PBS buffer,20mM GSH
Storage: Store at -20?, for extended storage, conserve at -20? or -80?.
Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
AA sequence: ATEHVNGNGTEEPMDTTSAVIHSENFQTLLDAGLPQKVAEKLDEIYVAGLVAHSDLDERAIEALKEFNEDGALAVLQQFKDSDLSHVQNKSAFLCGVMKTYRQREKQGTKVADSSKGPDEAKIKALLERTGYTLDVTTGQRKYGGPPPDSVYSGQQPSVGTEIFVGKIPRDLFEDELVPLFEKAGPIWDL
Referrences: [1] "A novel heterogeneous nuclear ribonucleoprotein-like protein interacts with NS1 of the minute virus of mice." Harris C.E., Boden R.A., Astell C.R. J. Virol. 73:72-80(1999) [PubMed: 9847309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), INTERACTION WITH NS1. Tissue: Cervix carcinoma. [2] "Cloning of human and mouse GRY-RBP cDNA." Du G., Pan M., Zhou Y., Chen J., Yao H., Yuan J., Qiang B. Chin. Sci. Bull. 45:343-349(2000) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). [3] "SMN interacts with a novel family of hnRNP and spliceosomal proteins." Mourelatos Z., Abel L., Yong J., Kataoka N., Dreyfuss G. EMBO J. 20:5443-5452(2001) [PubMed: 11574476] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), FUNCTION IN MRNA PROCESSING, SUBCELLULAR LOCATION, ASSOCIATION WITH THE SPLICEOSOME, INTERACTION WITH SMN AND HNRPR. Tissue: Cervix carcinoma. [4] Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Liver.
Alias: Glycine- and tyrosine-rich RNA-binding protein,NS1-associated protein 1,Synaptotagmin-binding, cytoplasmic RNA-interacting protein.

Информация для заказа

Область использования: Рекомбинантные белки Cusabio	Производство:	Cusabio
	Метод:
	Объем:	200 мкг
	Кат. номер:	CSB-RP033344h
Цена (с НДС 20%):	по запросу	В корзину
Наименование: Recombinant human Heterogeneous nuclear ribonucleoprotein Q protein. Примечание: дополнительная информация (на английском языке).