Recombinant human Intercellular adhesion molecule 1 protein

Relevance: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.
Product Info: GST tagged
Source: E.coli derived
Purity: 90%
Image:
Tested applications: SDS-PAGE, ELISA
Storage Buffer: PBS buffer, 20mM GSH
Storage: Store at -20?, for extended storage, conserve at -20? or -80?.
Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
AA sequence: MAPSSPRPALPALLVLLGALFPGPGNAQTSVSPSKVILPRGGSVLVTCSTSCDQPKLLGIETPLPKKELLLPGNNRKVYELSNVQEDSQPMCYSNCPDGQSTAKTFLTVYWTPERVELAPLPSWQPVGKNLTLRCQVEGGAPRANLTVVLLRGEKELKREPAVGEPAEVTTTVLVRRDHHGANFSCRTELDLRPQGLELFENTSAPYQLQTFVLPATPPQLVSPRVLEVDTQGTVVCSLDGLFPVSEAQVHLALGDQRLNPTVTYGNDSFSAKASVSVTAEDEGTQRLTCAVILGNQSQETLQTVTIYSFPAPNVILTKPEVSEGTEVTVKCEAHPRAKVTLNGVPAQPLGPRAQLLLKATPEDNGRSFSCSATLEVAGQLIHKNQTRELRVLYGPRLDERDCPGNWTWPENSQQTPMCQAWGNPLPELKCLKDGTFPLPIGESVTVTRDLEGTYLCRARSTQGEVTRKVTVNVLSPRYEIVIITVVAAAVIMGTAGLSTYLYNRQRKIKKYRLQQAQKGTPMKPNTQATPP
Referrences: [1] "ICAM, an adhesion ligand of LFA-1, is homologous to the neural cell adhesion molecule NCAM." Simmons D., Makgoba M.W., Seed B. Nature 331:624-627(1988) [PubMed: 3340213] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLU-469. [2] "Primary structure of ICAM-1 demonstrates interaction between members of the immunoglobulin and integrin supergene families." Staunton D.E., Marlin S.D., Stratowa C., Dustin M.L., Springer T.A. Cell 52:925-933(1988) [PubMed: 3349522] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLU-469. [3] "cDNA cloning reveals that the major group rhinovirus receptor on HeLa cells is intercellular adhesion molecule 1." Tomassini J.E., Graham D., Dewitt C.M., Lineberger D.W., Rodkey J.A., Colonno R.J. Proc. Natl. Acad. Sci. U.S.A. 86:4907-4911(1989) [PubMed: 2544880] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Alias: Major group rhinovirus receptor,CD54.

Информация для заказа

Область использования: Рекомбинантные белки Cusabio	Производство:	Cusabio
	Метод:
	Объем:	200 мкг
	Кат. номер:	CSB-RP071444h
Цена (с НДС 20%):	по запросу	В корзину
Наименование: Recombinant human Intercellular adhesion molecule 1 protein. Примечание: дополнительная информация (на английском языке).