Recombinant human Leptin protein
Relevance: May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass.
Product Info:
Source:
Purity: 90%
Image:
Tested applications: SDS-PAGE, ELISA
Storage Buffer: PBS buffer, 20mM GSH
Storage: Store at -20?, for extended storage, conserve at -20? or -80?.
Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
AA sequence:
Referrences: [1] "Positional cloning of the mouse obese gene and its human homologue." Zhang Y., Proenca P., Maffei M., Barone M., Leopold L., Friedman J.M. Nature 372:425-432(1994) [PubMed: 7984236] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. [2] Erratum Zhang Y., Proenca P., Maffei M., Barone M., Leopold L., Friedman J.M. Nature 374:479-479(1995) [3] "Human obese gene expression. Adipocyte-specific expression and regional differences in the adipose tissue." Masuzaki H., Ogawa Y., Isse N., Satoh N., Okazaki T., Shigemoto M., Mori K., Tamura N., Hosoda K., Yoshimasa Y., Jingami H., Kawada T., Nakao K. Diabetes 44:855-858(1995) [PubMed: 7789654] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. [4] "Genomic structure and promoter analysis of the human obese gene." Gong D.W., Bi S., Pratley R.E., Weintraub B.D. J. Biol. Chem. 271:3971-3974(1996) [PubMed: 8626726] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. [5] Chehab F.F., Lim M.E. Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Alias: Obese protein,Obesity factor.
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