Recombinant human Mucin-1 protein

Relevance: The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack. Ref.26 Ref.37 Ref.40 Ref.45 Ref.46 Ref.49 Ref.52 Ref.53 Ref.56 The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. Modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity.
Product Info:
Source:
Purity: 90%
Image:
Tested applications: SDS-PAGE, ELISA
Storage Buffer: 6M guanidine hydrochloride, 20mM Tris
Storage: Store at -20?, for extended storage, conserve at -20? or -80?.
Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
AA sequence:
Referrences: [1] "Cloning and sequencing of a human pancreatic tumor mucin cDNA." Lan M.S., Batra S.K., Qi W.-N., Metzgar R.S., Hollingsworth M.A. J. Biol. Chem. 265:15294-15299(1990) [PubMed: 2394722] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Pancreatic carcinoma. [2] "Episialin, a carcinoma-associated mucin, is generated by a polymorphic gene encoding splice variants with alternative amino termini." Ligtenberg M.J.L., Vos H.L., Gennissen A.M.C., Hilkens J. J. Biol. Chem. 265:5573-5578(1990) [PubMed: 2318825] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2). [3] "Molecular cloning and expression of human tumor-associated polymorphic epithelial mucin." Gendler S.J., Lancaster C.A., Taylor-Papadimitriou J., Duhig T., Peat N., Burchell J., Pemberton L., Lalani E.-N., Wilson D. J. Biol. Chem. 265:15286-15293(1990) [PubMed: 1697589] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Mammary carcinoma.
Alias: Breast carcinoma-associated antigen DF3,Carcinoma-associated mucin,Episialin,H23AG,PEMT,Peanut-reactive urinary mucin,PUM,Polymorphic epithelial mucin,PEM,Tumor-associated epithelial membrane antigen,EMA,Tumor-associated mucin,CD227,Mucin-1 subunit alpha,MUC1-NT,MUC1-alpha2.Mucin-1 subunit beta,MUC1-beta,MUC1-CT.

Информация для заказа

Область использования: Рекомбинантные белки Cusabio	Производство:	Cusabio
	Метод:
	Объем:	500 мкг
	Кат. номер:	CSB-RP113174h
Цена (с НДС 20%):	по запросу	В корзину
Наименование: Recombinant human Mucin-1 protein. Примечание: дополнительная информация (на английском языке).