Recombinant human Profilin-1 protein

Relevance: Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.
Product Info: GST-tagged
Source: E.coli derived
Purity: 95%
Image:
Tested applications: SDS-PAGE, ELISA, Western blot.
Storage Buffer: PBS buffer,20mM GSH.
Storage: Store at -20?, for extended storage, conserve at -20? or -80?.
Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
AA sequence: AGWNAYIDNLMADGTCQDAAIVGYKDSPSVWAAVPGKTFVNITPAEVGVLVGKDRSSFYVNGLTLGGQKCSVIRDSLLQDGEFSMDLRTKSTGGAPTFNVTVTKTDKTLVLLMGKEGVHGGLINKKCYEMASHLRRSQY
Referrences: [1] "Human profilin. Molecular cloning, sequence comparison, and chromosomal analysis." Kwiatkowski D.J., Bruns G.A.P. J. Biol. Chem. 263:5910-5915(1988) [PubMed: 3356709] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. [2] "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon, Lung, Pancreas and Placenta. [3] "The primary structure of human platelet profilin: reinvestigation of the calf spleen profilin sequence." Ampe C., Markey F., Lindberg U., Vandekerckhove J. FEBS Lett. 228:17-21(1988) [PubMed: 3342873] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-140, ACETYLATION AT ALA-2. [4] "Distinct biochemical characteristics of the two human profilin isoforms." Gieselmann R., Kwiatkowski D.J., Janmey P.A., Witke W. Eur. J. Biochem. 229:621-628(1995) [PubMed: 7758455] [Abstract] Cited for: CHARACTERIZATION. [5] "Exportin 6: a novel nuclear export receptor that is specific for profilin.actin complexes." Stueven T., Hartmann E., Goerlich D. EMBO J. 22:5928-5940(2003) [PubMed: 14592989] [Abstract] Cited for: IDENTIFICATION IN A COMPLEX WITH RAN; ACTB AND XPO6.
Alias: Profilin I.

Информация для заказа

Область использования: Рекомбинантные белки Cusabio	Производство:	Cusabio
	Метод:
	Объем:	500 мкг
	Кат. номер:	CSB-RP041544h
Цена (с НДС 20%):	по запросу	В корзину
Наименование: Recombinant human Profilin-1 protein. Примечание: дополнительная информация (на английском языке).