Recombinant human Prostatic acid phosphatase protein

Relevance: A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma. Ref.11 Ref.13 Ref.15 Ref.18 Isoform 2: the cellular form also has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP which acts as a pain suppressor. Acts as a tumor suppressor of prostate cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling. Ref.11 Ref.13 Ref.15 Ref.18
Product Info:
Source:
Purity: 90%
Image:
Tested applications: SDS-PAGE, ELISA
Storage Buffer: 6M guanidine hydrochloride, 20mM Tris
Storage: Store at -20?, for extended storage, conserve at -20? or -80?.
Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
AA sequence:
Referrences: [1] "Structure of human prostatic acid phosphatase gene." Sharief F.S., Li S.S.-L. Biochem. Biophys. Res. Commun. 184:1468-1476(1992) [PubMed: 1375464] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1). [2] "Covalent structure, disulfide bonding, and identification of reactive surface and active site residues of human prostatic acid phosphatase." van Etten R.L., Davidson R., Stevis P.E., Macarthur H., Moore D.L. J. Biol. Chem. 266:2313-2319(1991) [PubMed: 1989985] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PARTIAL PROTEIN SEQUENCE, DISULFIDE BONDS, ACTIVE SITE. [3] "Human prostatic acid phosphatase: cDNA cloning, gene mapping and protein sequence homology with lysosomal acid phosphatase." Sharief F.S., Lee H., Leuderman M.M., Lundwall A., Deaven L.L., Lee C.-L., Li S.S.-L. Biochem. Biophys. Res. Commun. 160:79-86(1989) [PubMed: 2712834] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Alias: 5'-nucleotidase,5'-NT,Ecto-5'-nucleotidase,Thiamine monophosphatase,TMPase.

Информация для заказа

Область использования: Рекомбинантные белки Cusabio	Производство:	Cusabio
	Метод:
	Объем:	500 мкг
	Кат. номер:	CSB-RP113074h
Цена (с НДС 20%):	по запросу	В корзину
Наименование: Recombinant human Prostatic acid phosphatase protein. Примечание: дополнительная информация (на английском языке).