Recombinant human Sorting nexin-3 protein

Relevance: Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol-3-phosphate (PtdIns(P3)). Plays a role in protein transport between cellular compartments. Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G By similarity. Not involved in EGFR degradation.
Product Info: GST tagged
Source: E.coli derived
Purity: 95%
Image:

Tested applications: SDS-PAGE, ELISA, Western blot
Storage Buffer: 6M guanidine hydrochloride, 20mM Tris
Storage: Store at -20?, for extended storage, conserve at -20? or -80?.
Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
AA sequence: ETVADTRRLITKPQNLNDAYGPPSNFLEIDVSNPQTVGVGRGRFTTYEIRVKTNLPIFKLKESTVRRRYSDFEWLRSELERESKVVVPPLPGKAFLRQLPFRGDDGIFDDNFIEERKQGLEQFINKVAGHPLAQNERCLHMFLQDEIIDKSYTPSKIRHA
Referrences: [1] "Identification of a family of sorting nexin molecules and characterization of their association with receptors." Haft C.R., de la Luz Sierra M., Barr V.A., Haft D.H., Taylor S.I. Mol. Cell. Biol. 18:7278-7287(1998) [PubMed: 9819414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). [2] "SNX3 regulates endosomal function through its PX-domain-mediated interaction with PtdIns(3)P." Xu Y., Hortsman H., Seet L., Wong S.H., Hong W. Nat. Cell Biol. 3:658-666(2001) [PubMed: 11433298] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, PHOSPHOINOSITIDE-BINDING, DOMAIN PX, MUTAGENESIS OF 69-ARG--TYR-71 AND TYR-71. [3] "Homo sapiens sorting nexin 3A (SNX 3A) mRNA." Hayama A., Uchida S., Sasaki S., Marumo F. Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Alias: Protein SDP3.

Информация для заказа

Область использования: Рекомбинантные белки Cusabio	Производство:	Cusabio
	Метод:
	Объем:	500 мкг
	Кат. номер:	CSB-RP013254h
Цена (с НДС 20%):	по запросу	В корзину
Наименование: Recombinant human Sorting nexin-3 protein. Примечание: дополнительная информация (на английском языке).