Recombinant human Tenascin protein
Relevance: Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6.
Product Info:
Source:
Purity: 90%
Image:
Tested applications: SDS-PAGE, ELISA
Storage Buffer: 6M guanidine hydrochloride, 20mM Tris
Storage: Store at -20?, for extended storage, conserve at -20? or -80?.
Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
AA sequence:
Referrences: [1] "The complete cDNA sequence of human hexabrachion (Tenascin). A multidomain protein containing unique epidermal growth factor repeats." Nies D.E., Hemesath T.J., Kim J.H., Gulcher J.R., Stefansson K. J. Biol. Chem. 266:2818-2823(1991) [PubMed: 1704365] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS ARG-539; LEU-1677 AND GLN-2008. [2] "Human tenascin: primary structure, pre-mRNA splicing patterns and localization of the epitopes recognized by two monoclonal antibodies." Siri A., Carnemolla B., Saginati M., Leprini A., Casari G., Baralle F., Zardi L. Nucleic Acids Res. 19:525-531(1991) [PubMed: 1707164] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 4 AND 5), PROTEIN SEQUENCE OF 23-32, VARIANTS ARG-680 AND GLN-2008. Tissue: Fetal brain and Melanoma. [3] "Structure of the human hexabrachion (tenascin) gene." Gulcher J.R., Nies D.E., Alexakos M.J., Ravikant N.A., Sturgill M.E., Marton L.S., Stefansson K. Proc. Natl. Acad. Sci. U.S.A. 88:9438-9442(1991) [PubMed: 1719530] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS ARG-539; LEU-1677 AND GLN-2008.
Alias: Cytotactin GMEM GP 150-225 Glioma-associated-extracellular matrix antigen Hexabrachion JI Myotendinous antigen Neuronectin Tenascin-C Short name=TN-C.
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