Recombinant human Tyrosine-protein kinase ABL1 protein

Relevance: Protein kinase that regulates key processes linked to cell growth and survival. Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks.
Product Info: GST tagged
Source: E.coli derived
Purity: 90%
Image:

Tested applications: SDS-PAGE, ELISA
Storage Buffer: 6M guanidine hydrochloride, 20mM Tris
Storage: Store at -20?, for extended storage, conserve at -20? or -80?.
Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
AA sequence: ICLKLVGCKSKKGLSSSSSCYLEEALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNT
Referrences: [1] "Alternative splicing of RNAs transcribed from the human abl gene and from the bcr-abl fused gene." Shtivelman E., Lifshitz B., Gale R.P., Roe B.A., Canaani E. Cell 47:277-284(1986) [PubMed: 3021337] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM IA), ALTERNATIVE SPLICING, VARIANT PRO-140. [2] "Nucleotide sequence analysis of human abl and bcr-abl cDNAs." Fainstein E., Einat M., Gokkel E., Marcelle C., Croce C.M., Gale R.P., Canaani E. Oncogene 4:1477-1481(1989) [PubMed: 2687768] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM IA). Tissue: Fibroblast.
Alias: Abelson murine leukemia viral oncogene homolog 1,Proto-oncogene c-Abl,p150.

Информация для заказа

Область использования: Рекомбинантные белки Cusabio	Производство:	Cusabio
	Метод:
	Объем:	50 мкг
	Кат. номер:	CSB-RP043554h
Цена (с НДС 20%):	по запросу	В корзину
Наименование: Recombinant human Tyrosine-protein kinase ABL1 protein. Примечание: дополнительная информация (на английском языке).