Recombinant human V-set domain-containing T-cell activation inhibitor 1 protein

Relevance: Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.
Product Info:
Source:
Purity: 90%
Image:
Tested applications: SDS-PAGE, ELISA
Storage Buffer: 6M guanidine hydrochloride, 20mM Tris
Storage: Store at -20?, for extended storage, conserve at -20? or -80?.
Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
AA sequence:
Referrences: [1] "B7-H4, a molecule of the B7 family, negatively regulates T cell immunity." Sica G.L., Choi I.-H., Zhu G., Tamada K., Wang S.-D., Tamura H., Chapoval A.I., Flies D.B., Bajorath J., Chen L. Immunity 18:849-861(2003) [PubMed: 12818165] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Placenta. [2] "B7x: a widely expressed B7 family member that inhibits T cell activation." Zang X., Loke P., Kim J., Murphy K., Waitz R., Allison J.P. Proc. Natl. Acad. Sci. U.S.A. 100:10388-10392(2003) [PubMed: 12920180] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). [3] "B7-H3 and B7-H4 expression in non-small-cell lung cancer." Sun Y., Wang Y., Zhao J., Gu M., Giscombe R., Lefvert A.K., Wang X. Lung Cancer 53:143-151(2006) [PubMed: 16782226] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Alias: B7h.5 Immune costimulatory protein B7-H4 Protein B7S1 T-cell costimulatory molecule B7x.

Информация для заказа

Область использования: Рекомбинантные белки Cusabio	Производство:	Cusabio
	Метод:
	Объем:	50 мкг
	Кат. номер:	CSB-RP130074h
Цена (с НДС 20%):	по запросу	В корзину
Наименование: Recombinant human V-set domain-containing T-cell activation inhibitor 1 protein. Примечание: дополнительная информация (на английском языке).