Human IgM

Product Type: Native protein
Availability: 2 weeks
Source: Purified from pooled normal human serum
Peptide: Full length native human IgG
Application: Western blotting,ELISA,etc.
Purity: >95%(SDS-PAGE)
Relevance: IgM normally constitutes about 10% of serum immunoglobulins. IgM antibody is prominent in early immune responses to most antigens and predominates in certain antibody responses such as 'natural' blood group antibodies. IgM (with IgD) is the major immunoglobulin expressed on the surface of B cells. The gene for the mu constant region contains four domains separated by short intervening sequences. Class specific anti immunoglobulin antibodies are useful for: The characterization of malignant B cell proliferations. All but acute lymphocytic leukemias share either surface or intra cytoplasmic Ig with an isotypic restriction, which suggest the monoclonal nature of the cell population. Most of the chronic lymphocytic leukemias, non Hodgkin lymphomas and Burkitt's lymphoma bear surface IgM, whereas plasmocytes from Waldenström's disease bear intracytoplasmic IgM. The other isotypes are less frequently found. On the other hand multiple myelomas are usually of the IgG or IgA type. Characterization of plasma cells in inflammatory conditions: Plasma cell typing can be of use for the classification of intestinal inflammatory conditions such as inflammatory bowel disease and allergic conditions. In the latter a specific increase in the number of IgE plasma cells can be demonstrated.
Storage Buffer: PBS
Form: liquid
Stability & Storage : Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles
Alias:
Image:

Lane 1 IgM (reduced/heated)

Lane 2. IgM (reduced/heated)

Protein Molecular Weight Marker:116,66.2,45,35,25,18.4,14.4kD

Информация для заказа

Область использования: Белки производства Cusabio	Производство:	Cusabio
	Метод:
	Объем:	1 мг
	Кат. номер:	CSB-NP001401h
Цена (с НДС 20%):	по запросу	В корзину
Наименование: Human IgM. Примечание: дополнительная информация (на английском языке).